| OLOF EDLUND Antiquarian Bookseller STOCKHOLM |  |
| OLOF EDLUND Antiquarian Bookseller STOCKHOLM | |
| $ 780 |
| First edition. "Discovery of Balantidium coli, the first parasitic protozoon to be discovered and recognized as such"(G&M). A German translation appeared in Virchows Archiv f. pathologische Anatomie, vol. 12 (1857), pp. 302-9 + one plate. An English translation in B.H. Kean, et alia, Tropical medicine and parasitology: classic investigations. "Balantidium coli is a species of ciliate protozoan, and is the only one that is a pathogen of humans. It is carried by pigs, rats, primates (including humans), rats, horses, cattle and guinea pigs. It is transmitted within or between these species mostly via fecal transmission. Pigs are the most significant reservoir hosts, though they show few if any symptoms. A trophozoite of Balantidium coli Cysts are the parasite stage responsible for transmission of balantidiasis. The host most often acquires the cyst through ingestion of contaminated food or water. Following ingestion, excystation occurs in the small intestine, and the trophozoitescolonize the large intestine. Both cysts and trophozoites are identifiable by a large, "sausage shaped" macronucleus. The trophozoites reside in the lumen of the large intestine of humans and animals, where they replicate by binary fission, during which conjugation may occur . Trophozoites undergo encystation to produce infective cysts . Some trophozoites invade the wall of the colon and multiply. Some return to lumen and disintegrate. Mature cysts are passed with feces. Symptoms can be local due to involvement of the intestinal mucosa, or systemic in nature and include diarrhea. Balantidiasis can be treated by carbarsone, tetracycline, or diiodohydroxyquin. Less than 1% of the human population is infected worldwide"(www.mrsci.com). |
| * G&M 3455. Waller 6187a. SBL, 25, pp. 8-12. Sacklén, suppl., pp. 247-9. |